Dissolution Method Development and Validation for Lercanidipine Hydrochloride Tablets

Discriminatory Dissolution Method Development and Validation for Cephalexin Od Tablets

In this study, a discriminative dissolution method was developed for Cephalexin OD (orally disintegrating) tablets 750mg. The solubility and stability of the cephalexin API was determined in ten different solutions. In that 0.01N HCl, glycine buffer pH 3-0, acetate buffer pH 4.5 and water gave good stability and the solubility. Dissolution profiling of cephalexin OD tablets 750mg of single batc...

Development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets.

PURPOSE This study describes the development and validation of dissolution tests for fexofenadine hydrochloride capsules and coated tablets using an HPLC method. METHOD The appropriate conditions were determinate after testing sink conditions, dissolution medium, and agitation intensity. The apparatus, paddle and basket, were applied to tablets and capsules, respectively. Fexofenadine hydroch...

the development and validation of dissolution method for donepezil tablet

Analytical Method Development and Validation of Estimation Method for Sotalol Hydrochloride Tablets by Using Rp-hplc

The present investigation describes about a simple, economic, selective, accurate, precise Reverse phase High performance liquid chromatographic method for the estimation of Sotalol Hydrochloride in pharmaceutical dosage forms. Sotalol Hydrochloride was well eluted using a C18 column of dimension 100 × 4.6, 5μm and Mobile phase consisting of Acetonitrile: 20 mM Ammonium acetate buffer (pH-6): M...

Development and validation of dissolution method for carvedilol compression-coated tablets

The present study describes the development and validation of a dissolution method for carvedilol compression-coated tablets. Dissolution test was performed using a TDT-06T dissolution apparatus. Based on the physiological conditions of the body, 0.1N hydrochloric acid was used as dissolution medium and release was monitored for 2 hours to verify the immediate release pattern of the drug in aci...